发明名称 |
METHOD FOR PRODUCING PURINE NUCLEOSIDES BY FERMENTATION |
摘要 |
A microorganism which has a gene encoding an enzyme in which feedback inhibition is desensitized by substitution of one or two amino acids in PRPP amidotransferase encoded by purF of Escherichia coli, a gene encoding a protein which is an inactivated repressor of purine nucleotide biosynthesis encoded by purR, a gene encoding an enzyme which is inactivated purine nucleoside phosphorylase encoded by deoD, a gene encoding an enzyme which is inactivated succinyl-AMP synthase encoded by purA, a gene encoding an enzyme which is inactivated 6-phosphogluconate dehydrase encoded by edd, a gene encoding an enzyme which is inactivated phosphoglucose isomerase encoded by pgi and like is bred and a purine nucleoside is produced by culturing the microorganism. |
申请公布号 |
EP1577386(A2) |
申请公布日期 |
2005.09.21 |
申请号 |
EP20050007365 |
申请日期 |
1998.07.17 |
申请人 |
AJINOMOTO CO., INC. |
发明人 |
MATSUI, HIROSHI;KAWASAKI, HISASHI;SHIMAOKA, MEGUMI;TAKENAKA, YASUHIRO;KURAHASHI, OSAMU |
分类号 |
C12N1/21;C12N15/09;C12P19/40 |
主分类号 |
C12N1/21 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|