novel benzoxazinone derivatives as slow-acting betamimetics and use thereof in treatment of respiratory tract diseases

摘要

Benzoxazinone derivatives (I) are new. Benzoxazinone derivatives of formula (I) and their isomers and acid addition salts are new. n : 1 or 2; A : O or a bond; R : 1-6C alkyl or haloalkyl; R 1>-R 3>H, Q 1>, 1-6C haloalkyl, OH, Q 2>OH, OQ 1>, 6-10C aryl, (6-10C)aryl(1-4C)alkyl, (6-10C)aryl(1-6C)alkoxy, COOH, COOQ 1>, OQ 2>COOH, OQ 2>COOQ 1>, NHSO 3H, NHSO 2Q 1>, NH 2, NHQ 1>, N(Q 1>) 2, NO 2, SQ 1>, SO 2Q 1>, SOQ 1>, OCOQ 1>, COQ 1>, NHCOQ 1> or halo; Q 1>1-6C alkyl; Q 2>1-6C alkylene. [Image] ACTIVITY : Antiinflammatory; Antiasthmatic. No biological data given. MECHANISM OF ACTION : Beta mimetic.