VACCINE COMPRISING MIXTURES OF MULTIVALENT MENINGOCOCCAL OUTER MEMBRANE VESCILES.

摘要

The present invention relates to vaccine compositions for the effective prevention or treatment of neisserial, preferably meningococcal, disease. The vaccines of the invention comprise a multivalent meningococcal bled composition comprising at least one bleb with homologous bactericidal activity which is derived from a meningococcal strain with a serosubtype that is prevalent in a country of use, and at least one bleb with heterologous bactericidal activity which is derived from a meningococcal strain which need not have a serosubtype that is prevalent in the country of use.