发明名称 |
INHIBITING THE DEVELOPMENT OF TOLERANCE TO AND/OR DEPENDENCEON AN ADDICTIVE SUBSTANCE |
摘要 |
Nontoxic substances that block the N-methyl-D-aspartate (NMDA) receptor, e.g., a morphinan such as dextromethorphan or dextrorphan, or 'that block a major intracellular consequence of NMDA receptor activation, e.g., a ganglioside such as GM1 or GT1b, a phenothiazine such as trifluoperazine or a naphthalenesulfonamide such as N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide, inhibit the development of tolerance to and/or dependence on addictive drugs, e.g., narcotic analgesics such as morphine, codeine, etc.
|
申请公布号 |
CA2113515(C) |
申请公布日期 |
2005.09.20 |
申请号 |
CA19942113515 |
申请日期 |
1994.01.14 |
申请人 |
VIRGINIA COMMONWEALTH UNIVERSITY |
发明人 |
MAYER, DAVID J.;PRICE, DONALD D.;MAO, JIANREN;LYLE, JOHN W. |
分类号 |
A61K31/715;A61K31/045;A61K31/135;A61K31/18;A61K31/435;A61K31/445;A61K31/485;A61K31/505;A61K31/515;A61K31/54;A61K31/55;A61K45/00;A61K45/06;A61P25/04;A61P25/20;A61P25/24;A61P25/26;A61P25/30;A61P25/36;A61P43/00;(IPC1-7):A61K31/485;A61K31/33 |
主分类号 |
A61K31/715 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|