Interstrand crosslinking agents for DNA and compounds therefor

摘要

Compounds represented by the general formula (I): which two DNA strands can be interstrand-crossliked: <?in-line-formulae description="In-line Formulae" end="lead"?>A-L-B-X-B-L-A (I)<?in-line-formulae description="In-line Formulae" end="tail"?> wherein B represents a chemical structure capable of recognizing the nucleotide sequence of DNA; A represents a chemical structure capable of binding to one of the bases of DNA; L represents a linker by which the chemical structures of A and B can be linked to each other; X represents a spacer by which the A-L-B components can be linked to each other. A method of interstrand-crosslinking DNA by using these compounds; and medicinal compositions containing interstarand-crosslinking agents of DNA.