摘要 |
FIELD: organic chemistry, chemical technology, medicine. ^ SUBSTANCE: invention relates to a method for preparing the synthetic 5-aminolevulinic (5-amino-4-oxopentanoic) acid hydrochloride (5-ALA) representing an endogenous substance (metabolite). Method for preparing 5-ALA involves electrochemical reduction of 5-nitrolevulinic acid methyl ester in acid aqueous medium on graphite cathode at temperature 60-75°C and the current density value 2-10 A/dm2. 5-ALA can be used in medicine for photodiagnosis and photodynamic therapy of malignant tumors of different localization and for treatment of diseases of non-tumor nature also. Invention provides simplifying technology of synthesis of 5-ALA, improved economy indices and provides ecological safety of the process. ^ EFFECT: improved preparing method. ^ 4 ex |