| 摘要 |
FIELD: organic chemistry, chemical technology. ^ SUBSTANCE: invention relates to a method for preparing compounds of the formula (I): wherein R means halogen atom; R1 means hydrogen atom (H); R2 means cyano-group (CN); X means oxygen atom (O) or H, H; n = 2, 3, 4, and their acid-additive salts. If X means oxygen atom (O) then the method involves interaction of compound of the formula (II): with compound of the formula (III): R-(CH2)n-CO-L (III) wherein L means halogen atom or others in the process of Friedel-Crafts acylation reaction in the presence of Lewis metalhalides of type R'-Al(Cl)2 as a catalyst wherein R' means (C1-C6)-alkyl. Prepared compound of the formula (I) is isolated as a base or its acid-additive salts followed by reduction by using complex hydrides and activation with Lewis metalhalides of type R'-Al(Cl)2. Method provides preparing compounds with the yield 87-89%. ^ EFFECT: improved preparing method. ^ 3 cl, 4 ex |
