| 摘要 |
There are provided pharmaceutically-acceptable acid addition salts of compounds of formula I,
wherein
R 1 represents C 1-2 alkyl substituted by one or more fluoro substituents;
R 2 represents G 1-2 alkyl; n represents 0, 1 or 2; and wherein the acid addition salt is an inorganic acid addition salt, an organic acid addition salt, a carboxylic acid addition salt, a hydroxy acid addition salt or an amino acid addition salt; which salts are useful as prodrugs of competitive inhibitors of trypsin-like proteases, such as thrombin, and thus, in particular, in the treatment of conditions where inhibition of thrombin is required (e.g. thrombosis) or as anticoagulants. |
