Glucocorticoid mimetics, methods of making them, pharmaceutical compositions and uses thereof

摘要

Compounds of Formula (IA) and Formula (IB) where in R¹ stands for the following group (the dashed line indicates the point of attachment) and R², R³, R⁴, R⁵, R⁶, Y, Z, X¹ and X² are as defined herein for Formula (IA) and Formula (IB), or a tautomer, prodrug, solvate, or salt thereof; pharmaceutical compositions containing such compounds, and methods of modulating the glucocorticoid receptor function and methods of treating disease-states or conditions mediated by the glucocorticoid receptor function or characterized by inflammatory, allergic, or proliferative processes in a patient using these compounds.