A method for administering a therapeutic or diagnostic agent to a subject is described. The method includes providing a suspension of liposomes comprised of one or more of vesicle-forming lipids selected from (i) a vesicle-forming lipid derivatized with a hydrophilic polymer and (ii) a neutral lipopolymer, said liposomes being associated with said therapeutic or diagnostic agent, forming an aerosol of said liposome suspension; and administering the aerosol to the subject by inhalation. The liposome formulation delivers intact liposomal particles to the respiratory tract of said subject to form a depot of therapeutic agent therein with no observable provocation of an immune response, as measured by neutrophil or macrophage cell count in the lung after administration.
申请公布号
WO2004110493(A3)
申请公布日期
2005.09.15
申请号
WO2004US16962
申请日期
2004.05.27
申请人
ALZA CORPORATION;WONG, FRANCES, M., P.;DAS, ANUK;SEIDEMAN, JONATHAN;GUO, LUKE;HUANG, ANTHONY
发明人
WONG, FRANCES, M., P.;DAS, ANUK;SEIDEMAN, JONATHAN;GUO, LUKE;HUANG, ANTHONY