摘要 |
A method for detecting a mutation related to the gene encoding OAS 1. This and other disclosed mutations correlate with resistance of humans to viral infection including hepatitis C. Also provided is a therapeutic agent consisting of a protein or polypeptide encoded by the mutated gene, or a polynucleotide encoding the protein or polypeptide. Inhibitors of human OAS 1, including antisense oligonucleotides, methods, and compositions specific for human OASI, are also provided. |
申请人 |
ILLUMIGEN BIOSCIENCES, INC.;IADONATO, SHAWN, P.;MAGNESS, CHARLES, L.;ROSENBERG, GARY;SCHERER, CHRISTINA, A.;GUILLAUDEUX, THIERRY |
发明人 |
IADONATO, SHAWN, P.;MAGNESS, CHARLES, L.;ROSENBERG, GARY;SCHERER, CHRISTINA, A.;GUILLAUDEUX, THIERRY |