发明名称 HETEROCYCLIC COMPOUNDS FOR PREVENTING AND TREATING DISORDERS ASSOCIATED WITH EXCESSIVE BONE LOSS
摘要 This invention relates to pyrimidine compounds of formula (I), formula (I')' and formula (I''): formula (I) and pharmaceutically acceptable salts, solvates, clathrates, and prodrugs thereof, wherein R1, R2, R3, R4, R5, U, V, W, X, Y, Z, and n are defined herein. This invention also relates to compositions comprising these compounds and methods for using them. The compounds and compositions of this invention are useful to treat or prevent disorders associated with excessive bone loss, including, without limitation periodontal disease, non-malignant bone disorders (such as osteoporosis, Paget's disease of bone, osteogenesis imperfecta, fibrous dysplasia, and primary hyperparathyroidism) estrogen deficiency, inflammatory bone loss, bone malignancy, arthritis, osteopetrosis, and certain cancer-related disorders (such as hypercalcernia of malignancy (HCM), osteolytic bone lesions of multiple myeloma and osteolytic bone metastases of breast cancer and other metastatic cancers).
申请公布号 WO2005000404(A3) 申请公布日期 2005.09.15
申请号 WO2004US17064 申请日期 2004.05.28
申请人 SYNTA PHARMACEUTICALS, CORP.;ONO, MITSUNORI;SUN, LIJUN;WADA, YUMIKO;KOYA, KEIZO;NAGAI, MASAZUMI 发明人 ONO, MITSUNORI;SUN, LIJUN;WADA, YUMIKO;KOYA, KEIZO;NAGAI, MASAZUMI
分类号 A61K31/5375;A61P;A61P1/00;C07D239/48;C07D251/18;C07D251/52;C07D401/06;C07D401/12;C07D401/14;C07D413/04;C07D413/12;C07D413/14;C07D473/16 主分类号 A61K31/5375
代理机构 代理人
主权项
地址