发明名称 |
Anellierte 4-Carboxyamino-2-Methyl-1,2,3,4-Tetrahydrochinoline als CETP-Hemmer |
摘要 |
<p>Cholesteryl ester transfer protein inhibitors of formula I, pharmaceutical compositions containing such inhibitors and the use of such inhibitors to elevate certain plasma lipid levels, including high density lipoprotein-cholesterol and to lower certain other plasma lipid levels, such as LDL-cholesterol and triglycerides and accordingly to treat diseases which are exacerbated by low levels of HDL cholesterol and/or high levels of LDL-cholesterol and triglycerides, such as atherosclerosis and cardiovascular diseases in some mammals, including humans. <CHEM> R1, R3-R8 are as in the application, wherein R<5> and R<6> or R<6> or R<7> and/or R<7> and R<8> together form at least 1 4-8 membered ring.</p> |
申请公布号 |
DE69926582(D1) |
申请公布日期 |
2005.09.15 |
申请号 |
DE1999626582 |
申请日期 |
1999.09.14 |
申请人 |
PFIZER PRODUCTS INC., GROTON |
发明人 |
DENINNO, MICHAEL PAUL;RUGGERI, ROGER BENJAMIN;WESTER, RONALD THURE |
分类号 |
A61K31/4706;A61K31/473;A61K31/4741;A61K31/4745;A61P3/06;A61P9/00;A61P9/10;A61P43/00;C07D215/42;C07D215/58;C07D221/10;C07D221/16;C07D471/04;C07D491/04;C07D491/048;C07D491/056;C07D495/04;C07D513/04;(IPC1-7):C07D221/06;A61K31/445;C07D487/04 |
主分类号 |
A61K31/4706 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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