发明名称 |
COMPOUNDS DERIVED FROM 4-ANILINEQUINAZOLINES WITH ADENOSINE-KIASE INHIBITOR PROPERTIES |
摘要 |
<p>The present invention introduces compounds that are adenosine-kinase inhibitors. We provide a process of protecting tissues and organs like heart, brain and kidneys affected by ischemia, and of treating heart insufficiency, myocardium infarct, arrhythmia, arterial hypertension, atherosclerosis, coronary artery re-stenosis after angioplasty, chronic renal insufficiency, cerebral vascular accident, and chronic inflammatory diseases (e.g. rheumatoid arthritis). We also provide the adenosine-kinase inhibitor effect of compounds derived from quinazolines, which were previously known as reversible inhibitors of tyrosine-kinases from the family of epidermic growth factor receptors (EGFR).</p> |
申请公布号 |
WO2005085213(A1) |
申请公布日期 |
2005.09.15 |
申请号 |
WO2004BR00196 |
申请日期 |
2004.10.07 |
申请人 |
UNIVERSIDADE ESTADUAL DE CAMPINAS-UNICAMP;GOMES FRANCHINI, KLEBER;ABDALLA SAAD, MARIO, JOSE;RITTNER NETO, ROBERTO;MARIN, RODRIGO, MIGUEL;ROCCO APARECIDA, SILVANA |
发明人 |
GOMES FRANCHINI, KLEBER;ABDALLA SAAD, MARIO, JOSE;RITTNER NETO, ROBERTO;MARIN, RODRIGO, MIGUEL;ROCCO APARECIDA, SILVANA |
分类号 |
A61K31/517;C07D239/94;(IPC1-7):C07D239/94 |
主分类号 |
A61K31/517 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|