发明名称 |
Hb-954 as a target for modulating angiogenesis |
摘要 |
The invention describes assays for the identification of compounds useful for the modulation of angiogenesis. The methods of the invention involve cell-free and cell-based assays that identify compounds which bind to and/or activate or inhibit the activity of HB-954, a G protein-coupled receptor, optionally followed by an in vivo assay of the effect of the compound on angiogenesis. The invention also describes compounds which bind to and/or activate or inhibit the activity of HB-954 as well as pharmaceutical compositions comprising such compounds. In addition, the invention includes nucleic acid molecules comprising a nucleotide sequence encoding all or a portion of HB-954, gene therapy vectors comprising such sequences, polypeptides comprising all or a portion of HB-954 and antibodies directed against HB-954.
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申请公布号 |
US2005202017(A1) |
申请公布日期 |
2005.09.15 |
申请号 |
US20050525456 |
申请日期 |
2005.05.10 |
申请人 |
DIXON KATHARINE H.;LIAU GENE;SERDIKOFF CYNTHIA |
发明人 |
DIXON KATHARINE H.;LIAU GENE;SERDIKOFF CYNTHIA |
分类号 |
A61K38/00;A61K39/395;A61K48/00;C07K14/705;C07K16/30;C12N1/21;C12N15/12;G01N33/574;(IPC1-7):G01N33/574 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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