发明名称 |
ITPase gene polymorphisms associated with adverse durg reactions to azathioprine therapy |
摘要 |
The present invention provides methods for predicting a patient's risk of an adverse drug reaction to a thiopurine drug such as AZA or 6-MP by genotyping the patient for a polymorphism in the gene encoding ITPase (ITPA). The present invention also provides methods for predicting a patient's risk of an adverse drug reaction to a thiopurine drug by determining a level of ITPase activity or ITP in a sample from the patient. The present invention further provides methods for optimizing therapeutic efficacy in a patient receiving a thiopurine drug by determining whether the patient should be given an alternative drug based on the presence or absence of a polymorphism in the ITPA gene.
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申请公布号 |
US2005202483(A1) |
申请公布日期 |
2005.09.15 |
申请号 |
US20050060972 |
申请日期 |
2005.02.18 |
申请人 |
GUY'S AND ST. THOMAS' NHS FOUNDATION TRUST |
发明人 |
SANDERSON JEREMY D.;MARINAKI ANTHONY M. |
分类号 |
A61K31/522;A61K31/7076;C12Q1/68;(IPC1-7):C12Q1/68;A61K31/707 |
主分类号 |
A61K31/522 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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