发明名称 |
Sustained release compositions for delivery of pharmaceutical proteins |
摘要 |
The present invention provides sustained release compositions that can be manufactured easily while providing long duration of the pharmaceutically useful protein being delivered. The compositions comprise insoluble complexes of the pharmaceutically useful protein and a precipitating agent at an appropriate ratio to achieve a desired sustained release profile. The precipitating agent can be selected from a group of various agents including divalent metal cations, Hofmeister series salts and pH adjusters. Particularly provided are compositions comprising insulin that are suitable for pulmonary delivery.
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申请公布号 |
US2005203002(A1) |
申请公布日期 |
2005.09.15 |
申请号 |
US20050031031 |
申请日期 |
2005.01.07 |
申请人 |
TZANNIS STELIOS;DASOVICH NANCY;KUMAR SANDEEP;SADRZADEH NEGAR |
发明人 |
TZANNIS STELIOS;DASOVICH NANCY;KUMAR SANDEEP;SADRZADEH NEGAR |
分类号 |
A61K9/14;A61K38/28;A61L9/04;(IPC1-7):A61K38/28 |
主分类号 |
A61K9/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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