IMIDAZO '1,2-A' PYRAZINE COMPOUNDS WHICH INTERACT WITH PROTEIN KINASES

摘要

The present invention relates to a novel compounds of formula I, to pharmaceutical compounds, to processes for their preparation, as well as to the use of the compounds in the inhibition of protein kinases, in particular serine/threonine kinases, more particularly mitogen activated protein kinase, more particularly the c-Jun NH2-teminal kinases (JNKs). The invention also relates to the compounds for use in medicine and particularly n the prevention and/or treatment of a wide variety of diseases including inflammatory disorders, cancer, angiogenesis, diabetes, metabolic disease and neurological disorders.