| 摘要 |
The invention relates to DL-hydroxybenzenamides having anticonvulsive activity. According to the invention, novel anticonvulsants are synthesised which include the following compounds: DL-2-hydroxy-2-phenyl hexanamide, DL-2-hydroxy-2-(3', 4'- dichlorophenyl) hexanamide, DL-3-hydroxy-3-(3',5'-bistrifluoromethylphenyl)-pentanamide, DL-3-hydroxy-3-phenyl-heptanamide and DL-4-hydroxy-4-(4'-trifluoromethylphenyl) hexanamide. The above-mentioned compounds have sufficiently potent anticonvulsive activity against convulsions produced by pentylenetetrazol, as well as unexpected differences in anticonvulsive activity in relation to non-halogenated compounds. The invention also relates to methods for the synthesis of DL-hydroxybenzenamides as outlined in the examples.
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