| 发明名称 |
Thrombin-cleavable chimeric proteins |
| 摘要 |
The invention relates to chimeric proteins comprising an artificial sequence for cleavage by thrombin, in which the activation peptide is fibrinopeptide A. Preferably, said chimeric proteins are derived from the zymogen of a serine protease such as PC or FX, by replacing the activation peptide of said zymogen with fibrinopeptide A, or a portion thereof, comprising at least amino acids P<SUB>10 </SUB>to P<SUB>1 </SUB>of said fibrinopeptide.
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| 申请公布号 |
US2005202527(A1) |
申请公布日期 |
2005.09.15 |
| 申请号 |
US20050492191 |
申请日期 |
2005.03.11 |
| 申请人 |
LE BONNIEC BERNARD;MARQUE PIERRE-EMMANUEL;LOUVAIN VIRGINIE;CALMEI CLAIRE;BIANCHINI ELSA;AIACH MARTINE |
发明人 |
LE BONNIEC BERNARD;MARQUE PIERRE-EMMANUEL;LOUVAIN VIRGINIE;CALMEI CLAIRE;BIANCHINI ELSA;AIACH MARTINE |
| 分类号 |
C12N15/09;A61K31/7088;A61K38/00;A61K48/00;A61P7/02;A61P7/04;C07K14/745;C07K14/75;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N9/64;C12N15/57;(IPC1-7):C12P21/06;C07H21/04 |
主分类号 |
C12N15/09 |
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