| 摘要 |
Synthetic and/or recombinant biologically active peptide derivatives of PTH(1-28), comprising a biologically active peptide at least 90% identical to a peptide consisting essentially of the formula: <tables id="TABLE-US-00001" num="1"> <table frame="none" colsep="0" rowsep="0" tabstyle="monospace"> <tgroup align="left" colsep="0" rowsep="0" cols="3"> <colspec colname="1" colwidth="14PT" align="left"/> <colspec colname="2" colwidth="140PT" align="left"/> <colspec colname="3" colwidth="63PT" align="left"/> <TBODY VALIGN="TOP"> <ROW> <ENTRY/> </ROW> <ROW> <ENTRY>(a)</ENTRY> <ENTRY>X<SUB>01</SUB>ValSerGluIleGlnLeuMetHisAsn</ENTRY> <ENTRY>(SEQ ID NO:1);</ENTRY> </ROW> <ROW> <ENTRY/> <ENTRY>LeuGlyLysHisLeuAsnSerMetX<SUB>02</SUB>Arg</ENTRY> </ROW> <ROW> <ENTRY/> <ENTRY>ValGluTrpLeuArgLysLysLeu</ENTRY> </ROW> </TBODY> </TGROUP> </TABLE> </TABLES> (b) fragments thereof containing amino acids 1-24, 1-25, 1-26, or 1-27; (c) pharmaceutically acceptable salts thereof; or (d) N- or C-derivatives thereof; wherein: X<SUB>01 </SUB>is Ser, Ala or Gly; and X<SUB>02 </SUB>is Glu or Arg, provided that said peptide is not hPTH(1-26)NH<SUB>2</SUB>, hPTH(1-27)NH<SUB>2 </SUB>or hPTH(1-28)NH<SUB>2</SUB>.
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