| 摘要 |
The present invention provides a production method of D-alloisoleucine, a protected compound thereof or a salt thereof, which is industrially useful, and which efficiently produces D-alloisoleucine having a high purity, a protected compound thereof and a salt thereof, and more particularly, a method including steps (a) to (c): (a) carbamoylating L-isoleucine to give L-(N-carbamoyl)isoleucine, (b) conducting intramolecular dehydration condensation of L-(N-carbamoyl)isoleucine to give L-5-sec-butylhydantoin, and (c) conducting an enzyme reaction of L-5-sec-butylhydantoin with hydantoin racemase (HRase), D-hydantoinase (D-HHase) and N-carbamoyl-D-amino acid hydrolase (D-CHase) to give D-alloisoleucine.
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