发明名称 |
FLUORESCENT SILICA-BASED NANOPARTICLES |
摘要 |
<p>The present invention provides nanoparticle compositions comprising, for example, a core comprising a fluorescent silane compound; and a silica shell on the core. Also provided are methods for the preparation of nanoparticle compositions including fluorescent nanoparticles, ligated-fluorescent nanoparticles, ligated-fluorescent nanoparticles having therapeutic agents, and ligated-fluorescent nanoparticles coupled or associated with an analyte. Also provided are methods: for the detection of the ligated-fluorescent nanoparticles; for associating the linked-fluorescent nanoparticles with a cellular component of interest and recording or monitoring the movement of the cellular component; for improving the therapeutic properties of the therapeutic agent by combining the therapeutic agent with linked-fluorescent nanoparticles and contacting or administering the combination to a cell or organism; for making and using the fluorescent nanoparticles in, for example, diagnostic agents for the detection of various analytes, and like applications.</p> |
申请公布号 |
EP1572445(A2) |
申请公布日期 |
2005.09.14 |
申请号 |
EP20030815995 |
申请日期 |
2003.11.26 |
申请人 |
CORNELL RESEARCH FOUNDATION, INC.;WIESNER, ULRICH B.;OW, HOOISWENG;LARSON, DANIEL E.;WEBB, WATT W. |
发明人 |
WIESNER, ULRICH;OW, HOOISWENG;LARSON, DANIEL, R.;WEBB, WATT, W. |
分类号 |
G01N33/50;G01N33/58;(IPC1-7):B32B5/16;G01N33/553;C09K11/02;H01L33/00 |
主分类号 |
G01N33/50 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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