摘要 |
Isolated human monoclonal antibodies which specifically bind to human EGFR, and related antibody-based compositions and molecules, are disclosed. The human antibodies can be produced by a transfectoma or in a non-human transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, non-human transgenic animals and hybridomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies. |
申请人 |
GENMAB A/S |
发明人 |
VAN DE WINKEL, JAN, G., J.;VAN DIJK, MARCUS, ANTONIUS;HALK, EDWARD;GERRITSEN, ARNOUT, F.;PETERSEN, JORGEN;BAADSGAARD, OLE;BLEEKER, WILLEM, KAREL;PARREN, PAUL |