发明名称 |
ALBUMIN-FUSED KUNITZ DOMAIN PEPTIDES |
摘要 |
An albumin fusion protein comprising the DX-88 Kunitz domain peptide or a fragment or variant thereof, and albumin or a fragment or variant thereof. Suitably, the albumin fusion protein exhibits an extended in vivo half-life, greater in vivo and/or in vitro biological activity and/or greater solubility than the DX-88 Kunitz domain peptide, or fragment or variant thereof, in an unfused state. Use of the albumin fusion protein in medicine; nucleic acid molecules encoding the albumin fusion protein; methods of making the albumin fusion protein. |
申请公布号 |
EP1572930(A2) |
申请公布日期 |
2005.09.14 |
申请号 |
EP20030737682 |
申请日期 |
2003.02.07 |
申请人 |
DELTA BIOTECHNOLOGY LIMITED;DYAX CORP. |
发明人 |
HAUSER, HANS-PETER;WEIMER, THOMAS;ROMBERG, VAL;KEE, SCOTT, M.;SLEEP, DARRELL;LADNER, ROBERT, CHARLES;LEY, ARTHUR, C. |
分类号 |
C07K14/765;C12N15/09;A61K9/00;A61K38/00;A61K38/55;A61K39/00;A61K39/395;A61K47/48;A61K48/00;A61P1/04;A61P7/04;A61P7/10;A61P9/02;A61P9/10;A61P17/02;A61P17/06;A61P19/04;A61P27/02;A61P29/00;A61P31/10;A61P31/18;A61P35/00;A61P37/02;A61P37/04;A61P39/02;C07K14/16;C07K14/47;C07K14/76;C07K14/78;C07K14/81;C07K19/00;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N9/99;C12N15/14;C12N15/15;C12N15/62;C12N15/81;C12P21/02;(IPC1-7):C12N1/00 |
主分类号 |
C07K14/765 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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