发明名称 |
METHOD OF IDENTIFICATION AND QUANTIFICATION OF PROTEINS, ISOFORMS OF THE ANGIOTENSIN I CONVERTING ENZYME |
摘要 |
The present invention relates to a method of identification and quantification of proteins, isoforms of angiotensin I converting enzymes (ACE), 190-kDa, specially of 90kDa in tissues, cells and biological fluids, specially in urine, genetic marker and prognostic agent of hypertension and primary or secondary renal lesion and kit for using in the diagnosis, risk stratification and therapeutical decision in arterial hypertension. One the aims of the present invention is to check the potential of the 90 kDa isoform as a hypertension genetic marker isoform and as a prognostic for hypertension. |
申请公布号 |
EP1573059(A1) |
申请公布日期 |
2005.09.14 |
申请号 |
EP20030779591 |
申请日期 |
2003.12.22 |
申请人 |
UNIVERSIDADE FEDERAL DE SAO PAULO - UNIFESP;FUNDACAO DE AMPARO A PESQUISA DO ESTADO DE SAO PAULO - FAPESP |
发明人 |
CASARINI, DULCE, ELENA;MARSON, ODAIR;PLAVNIK, FRIDA, LIANE;KRIEGER, JOSE, EDUARDO |
分类号 |
C12Q1/37;C12Q1/00;G01N33/50 |
主分类号 |
C12Q1/37 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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