发明名称 |
A process for producing a simvastatin precursor |
摘要 |
This invention provides an easy and efficient process for producing a simvastatin of great use as an HMG-CoA reductase inhibitor, which comprises deacylation of lovastatin with an inorganic base and a secondary or tertiary alcohol and subjecting the resulting did lactone to selective protection with a ketal or acetal protective group, acylation and deprotection-lactonization to give simvastatin. |
申请公布号 |
EP1533308(A3) |
申请公布日期 |
2005.09.14 |
申请号 |
EP20040023298 |
申请日期 |
1999.12.10 |
申请人 |
KANEKA CORPORATION |
发明人 |
TAOKA, NAOAKI;INOUE, KENJI |
分类号 |
E01F9/011;C07D309/30;C07D319/06 |
主分类号 |
E01F9/011 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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