发明名称 |
ASTHMA SUSCEPTIBILITY LOCUS |
摘要 |
The present invention describes a susceptibility locus which is functionally related to asthma. The locus maps within human chromosome 7p15-p14. The invention also describes a novel human gene, GPRA. The invention provides diagnostic methods and materials for analysing allelic variation in said locus and the GPRA gene. The invention also provides polypeptides encoded by GPRA gene and antibodies binding to said polypeptides. The invention further provides pharmaceutical compositions for the treatment of asthma, other IgE-mediated disease, chronic obstructive pulmonary disease or cancer. |
申请公布号 |
EP1572739(A1) |
申请公布日期 |
2005.09.14 |
申请号 |
EP20030767837 |
申请日期 |
2003.12.19 |
申请人 |
GENEOS OY |
发明人 |
LAITINEN, TARJA;KERE, JUHA;LAITINEN, LAURI, A.;POLVI, ANNE;MAEKELAE, SIRU;VENDELIN, JOHANNA;PULKKINEN, VILLE;SALMIKANGAS, PAULA |
分类号 |
A61K38/00;A61P11/06;C07K14/705;C07K16/28;C12Q1/68;(IPC1-7):C07K14/705;A61K38/17;C12N5/12 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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