摘要 |
The invention provides peptide derivatives designed to deliver peptides having growth factor inhibitory activity, especially somatostatin analogs, to the retina by sequential metabolism. The peptide derivatives, which comprise a dihydropyridine <img id="CUSTOM-CHARACTER-00001" he="2.46mm" wi="2.12mm" file="US06943145-20050913-P00900.TIF" alt="custom character" img-content="character" img-format="tif"/> pyridinium salt-type redox targetor moiety, a bulky lipophilic function and an amino acid/dipeptide/tripeptide spacer, are used in the prevention and treatment of diabetic retinopathy.
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