| 摘要 |
FIELD: pharmaceutical chemistry, medicine. ^ SUBSTANCE: invention relates to substituted pyridines and pyridazines with angiogenesis inhibition activity of general formula I ^ (I)1, wherein ring containing A, B, D, E, and L represents phenyl or nitrogen-containing heterocycle; X and Y are various linkage groups; R1 and R2 are identical or different and represent specific substituents or together form linkage ring; ring J represents aryl, pyridyl or cycloalkyl; and G's represent various specific substituents. Also disclosed are pharmaceutical composition containing claimed compounds, as well as method for treating of mammalian with abnormal angiogenesis or treating of increased penetrability using the same. ^ EFFECT: new pyridine and pyridazine derivatives with angiogenesis inhibition activity. ^ 26 cl, 6 tbl, 114 ex |
