ANTHRAX CONJUGATE VACCINE AND ANTIBODIES

摘要

The present invention is directed to immunogenic conjugates comprised of poly-gamma-D-glutamic acid (PGA) which has been covalently bound to protective antigen (PA). The invention includes methods for making conjugates, vaccines in which they are present and methods for immunizing individuals in which they are used. Conjugation produces a synergistic effect dramatically increasing the response of animals to both the PGA and PA components of the conjugate. Antibodies to PGA and PA confer protection against bacilli and anthrax toxins.