摘要 |
The invention provides a human KCNK2 which is associated with the cardiovascular diseases, dermatological diseases, endocrinological diseases, cancer (e.g. thyroid, esophagus, stomach, ileum, lung, breast tumor), gastroenterological diseases, hematological diseases, neurological diseases (e.g. Alzheimer), urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, dermatological diseases, endocrinological diseases, cancer, gastroenterological diseases, hematological diseases, neurological diseases, urological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of KCNK2 as well as pharmaceutical compositions comprising such compounds. |
申请人 |
BAYER HEALTHCARE AG;GOLZ, STEFAN;BRUEGGEMEIER, ULF;GEERTS, ANDREAS |
发明人 |
GOLZ, STEFAN;BRUEGGEMEIER, ULF;GEERTS, ANDREAS |