发明名称 |
DIAGNOSIS OR TREATMENT OF ENDOTHELIAL CELL DYSFUNCTION RELATED DISEASES |
摘要 |
The present invention provides a method of determining the disease state of a disease or condition associated with EC dysfunction in a subject. An exemplary method screens for elevated profilin-1 levels as a marker for DVD and other vascular diseases such as atherosclerosis, cerebrovascular disease, CVD or peripheral vascular disease. The invention also provides a method for the prophylaxis or treatment of such diseases or conditions associated with EC dysfunction. The method comprises administering to a subject a therapeutic composition or carrying out a protocol to inhibit the activity or function of profilin-1. In an embodiment, the composition comprises an inhibitor of profilin-1 activity or function administered in a pharmaceutically acceptable carrier. The therapeutic protocol or method can, for instance, be siRNA based or a strategy for gene therapy. The invention further provides a kit that can be used to carry out a diagnostic method. |
申请公布号 |
WO2005081945(A2) |
申请公布日期 |
2005.09.09 |
申请号 |
WO2005US05668 |
申请日期 |
2005.02.22 |
申请人 |
THE SCHEPENS EYE RESEARCH INSTITUTE, INC.;KAZLAUSKAS, ANDRIUS;ROMEO, GUILIO |
发明人 |
KAZLAUSKAS, ANDRIUS;ROMEO, GUILIO |
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