METHOD OF ASYMMETRICALLY REDUCING 4-[5-(IMIDAZOL-1-YL)-2-METHYLBENZOYL]-3,5-DIMETHYL­BENZOIC ACID OR ESTER THEREOF

摘要

A process for producing an optically active 4-[hydroxy[5-(imidazol-1-yl)-2- methylphenyl]methyl]3,5~dimethylbenzoic acid or an ester thereof, characterized by reacting 4-[5-(imidazol-1-yl)-2-methylbenzoyl]-3,5- di~methylbenzoic acid or an ester thereof with a silane agent in the presenc e of a specific zinc compound and an optically active diamine compound.