RATIONALLY DESIGNED ANTIBODIES HAVING A DOMAIN-EXCHANGED SCAFFOLD

摘要

Domain-exchanged antibodies having CDR regions replaced or fused with biologically active peptides are described. Flanking sequences may optionally be attached at one or both the carboxy-terminal and amino-terminal ends of the peptide in covalent association with adjacent framework regions. Compositions containing such modified domain-exchanged antibodies are useful in therapeutic and diagnostic modalities.