USE OF FGF INHIBITING SUBSTITUTED 1,2,3 INDOLIZINE DERIVATIVES IN THE PREPARATION OF MEDICAMENTS WHICH CAN BE USED TO TREAT DISEASES LINKED TO PATHOLOGICAL CHOROIDAL ANGIOGENESIS

摘要

The invention relates to the use of subsituted1,2,3 indolizine derivatives in the preparation of medicaments which can be used to treat diseases linked to pathological choroidal angiogenesis. The derivatives correspond to general formula (1) wherein R1 represents -OH, alcoxy(C1-C5), carboxy, alcoxycarbonyl (C2-C6), -NR5R6, -NH-SO2-Alk, -NH-SO2-Ph, -NH-CO-Ph, -N(Alk)-CO-Ph, -NH-CO-NH-Ph, -NH-CO-AIk, -NH-CO2-Alk, -O-(CH2)n-cAlk, -O-Alk-COOR7, -O-Alk-O-R8, -O-Alk-OH, -O-Alk-C(NH2):NOH, -O-Alk-NR5R6, -O-Alk-CN, -O-(CH2)n-Ph, -O-Alk-CO-NR5R6, -CO-NH-(CH2)m-COOR7, -CO-NH-Alk; R2 represents H, alkyl(C1-C5), alkyl halide (C1-C5), cycloalkyllC3-C6) or phenyl which is optionally substituted; A represents -CO-, -SO- or -SO2-, R3 and R4 are identical or different and each represents H, alcoxy(C1-C5), amino, carboxy, alcoxycarbonyl (C2-C6), -OH, nitro, hydroxyamino, -Alk-COOR7, -NR5R6, -NH-Alk-COOR7, -NH-COO-Alk, -N(R11)-SO2-Alk-NR9R10, N(R11)-SO2-Alk, -N(R11)-Alk-NR5R6, -N(R11)-CO-Alk-NR9R10, -N(R11)-CO-Alk, - N(R11)-CO-CF3, -NH-Alk-HetN, -O-Alk-NR9R10, -O-Alk-CO-NR5R6, -O-Alk-HetN, or R3 and R4 form together an unsaturated heterocycle with 5 to 6 chain links, optionally in the form of one of the pharmaceutically acceptable links thereof.