COMPOSITION FOR THE TREATMENT OF OBESITY COMPRISING FUMAGILLOL DERIVATIVE

摘要

Disclosed herein is a composition for the treatment of obesity which comprises a compound selected from the group consisting of O-(4-methoxycinnamoyl)fumagillol, O-(3,4,5-trimethoxycinnamoyl)fumagillol, O-(4-dimethylaminoethoxycinnamoyl)fumagillol, and salts thereof; and a pharmaceutically acceptable carrier. Since the composition potently inhibits the proliferation and increases the apoptosis of vein endothelial cells in adipose tissues to reduce the adipose tissues, and decreases food intake to cause weight loss, it shows superior therapeutic effects on obesity with few or no side effects.