TRANSGENNIC ANIMAL ALLOWING INDUCTIVE DELETION OF OSTEOCYTES

摘要

It is intended to provide a DNA construct which is usable in producing a transgenic animal allowing the inductive deletion of osteocytes. Namely, it is intended to provide a DNA constrct enabling the inductive deletion of osteocytes in a host by administering a compound essentially showing no toxicity to the host. This DNA construct comprises a DNA encoding a receptor binding to the above compound and a DMP1 gene promoter attached in such a manner that it can exert its function on the DNA. Due to the binding of the compound to the receptor, cells expressing the receptor are exterminated.