| 发明名称 |
Monomethylvaline compounds capable of conjugation to ligands |
| 摘要 |
Auristatin peptides, including MeVal-Val-Dil-Dap-Norephedrine (MMAE) and MeVal-Val-Dil-Dap-Phe (MMAF), were prepared and attached to Ligands through various linkers, including maleimidocaproyl-val-cit-PAB. The resulting ligand drug conjugates were active in vitro and in vivo. |
| 申请公布号 |
AU2004316290(A2) |
申请公布日期 |
2005.09.09 |
| 申请号 |
AU20040316290 |
申请日期 |
2004.11.05 |
| 申请人 |
SEATTLE GENETICS, INC. |
发明人 |
PETER D. SENTER;SUSAN D. SPENCER;ALLEN J. EBENS;PAUL POLAKIS;MARK X. SLIWKOWSKI;BRIAN E. TOKI;TONI BETH KLINE;SVETLANA O. DORONINA |
| 分类号 |
A61K38/00;A61K38/06;A61K39/395;A61K47/48;C07K16/46 |
主分类号 |
A61K38/00 |
| 代理机构 |
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代理人 |
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