发明名称 |
Process to increase the production of clavam antibiotics. |
摘要 |
A process for increasing the amount of clavam produced by an organism having both a clavam pathway or a portion thereof and a cephalosporin pathway or a portion thereof by interfering with the conversion of L-lysine to L-alpha-aminoadipic acid in the cephalosporin pathway. Plasmids containing a defective LAT (lysine amino transferase) gene and organisms containing such plasmids are also provided. |
申请公布号 |
HK1010087(A1) |
申请公布日期 |
2005.09.09 |
申请号 |
HK19980110939 |
申请日期 |
1998.09.24 |
申请人 |
SMITHKLINE BEECHAM PLC. |
发明人 |
WILLIAM HENRY HOLMS;ASHISH SUDHAKAR PARADKAR;ROY HENRY MOSHER |
分类号 |
C12N15/09;C12N1/21;C12N9/10;C12N15/54;C12P17/18 |
主分类号 |
C12N15/09 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|