Compositions containing beta 2-glycoprotein I for the prevention and/or treatment of vascular disease

摘要

Methods and compositions employing beta₂-glycoprotein-1 (beta₂GPI) or derivatives of beta₂GPI effective in inducing mucosal tolerance to atheroma related antigens, thus inhibiting inflammatory processes contributing to atheromatous vascular disease and sequalae, are provided. Also provided are articles of manufacture comprising mucosal tolerance inducing amounts of beta₂-glycoprotein-1 46 (beta₂GPI) or derivatives thereof.