Diamino thiazoloindan derivatives and their use

摘要

The subject invention provides a compound having the structure: wherein Y is O, NR₃R₄ or NOR₆; R₃ is H, alkyl, aralkyl, alkynyl, trifluoroacetyl, t-butoxycarbonyl or an acyl group; R₄ is H, alkyl, aralkyl, or alkynyl; R₆ is H or C₁-C₄ alkyl; R₁ and R₂ are each independently H, alkyl, aralkyl, or alkynyl; the curved line drawn from S to the center of the phenyl ring and the straight line drawn from N to the center of the ring indicate that S and N are part of a 5 membered ring which shares two carbons with the phenyl ring; and the dashed line drawn from the carbon atom on the cyclopentyl ring to Y represents a bond when Y is O or NOR₆ and is absent when Y is NR₃R₄, and wherein wherein X is H or O; and R₅ is H, alkyl, trifluoroacetyl, t-butoxycarbonyl or an acyl group, or an enantiomer, or a tautomer, or a pharmaceutically acceptable salt thereof, a process for preparing the compounds and a method of treating Parknison's disease, multiple sclerosis or depression with the compounds of the invention.