摘要 |
<p><P>PROBLEM TO BE SOLVED: To provide a method for producing a 2-oxazolidinone from aβ-aminoalcohol in a high yield in excellent operability. <P>SOLUTION: Aβ-aminoalcohol is reacted with phosgene in a two phase-based solvent composed of a nitrile and water to produce a 2-oxazolidinone. An aliphatic nitrile such as butyronitrile or isobutyronitrile is suitably used as the nitrile solvent. The reaction may be carried out in the presence of a base such as a metal hydroxide, a nitrogen-containing heteroaromatic compound, a tertiary amine, etc. <P>COPYRIGHT: (C)2005,JPO&NCIPI</p> |