HIV inhibiting pyrimidine derivatives

摘要

This invention concerns the use of the compounds of formula the N-oxides, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein A is CH, CR⁴ or N; n is 0 to 4; Q is hydrogen or -NR¹R²; R¹ and R² are selected from hydrogen, hydroxy, C_1-12alkyl, C_1-12alkyloxy, C_1-12alkylcarbonyl, C_1-12alkyloxycarbonyl, aryl, amino, mono- or di(C_1-12alkyl)-amino, mono- or di(C_1-12alkyl)aminocarbonyl wherein each C_1-12alkyl may optionally be substituted; or R¹ and R² taken together may form pyrrolidinyl, piperidinyl, morpholinyl, azido or mono- or di(C_1-12alkyl)aminoC_1-4alkylidene; R³ is hydrogen, aryl. C_1-6alkylcarbonyl, optionally substituted C_1-6alkyl, C_1-6alkyloxy-carbonyl; and R⁴ is hydroxy, halo, optionally substituted C_1-6alkyl, C_1-6alkyloxy, cyano, aminocarbonyl, nitro, amino, trihalomethyl, trihalomethyloxy; R⁵ is hydrogen or C_1-4alkyl; L is optionally substituted C_1-10alkyl, C_3-10alkenyl, C_3-10alkynyl, C_3-7cycloalkyl; or L is -X¹-R⁶ or -X²-Alk-R⁷ wherein R⁶ and R⁷ are optionally substituted phenyl; X¹ and X² are -NR³-, -NH-NH-, -N-N-, -O-, -S-, -S(-O)- or -S(-O)₂-; Alk is C_1-4alkanediyl; aryl is potionally substituted phenyl; Het is an optionally substituted aliphatic or aromatic heterocyclic radical; for the manufacture of a medicine for the treatment of subjects suffering from HIV (Human Immunodeficiency Virus) infection. It further relates to new compounds being a subgroup of the compounds of formula (I), their preparation and compositions comprising them.