发明名称 |
Tolperisone-containing pharmaceutical preparation with controllable active-substance release for oral administration |
摘要 |
The invention relates to a tolperisone-containing pharmaceutical preparation with controllable active-substance release for oral administration, characterised in that the active substance tolperisone and/or a pharmaceutical salt thereof is embedded in a pharmaceutically compatible material. By selecting the pharmaceutically compatible materials in the preparation and accordingly in the coating of a tablet or granule, a specific release of active substance can be adjusted which is matched to the special genotype in the metabolisation of tolperisone. At the same time, as a result of the very uniform and persistent release of tolperisone, the in-vivo inversion of enantiomerically pure tolperisone that is known from the art can be adjusted in favour of the R(-) tolperisone which is prominent in muscle-relaxing therapy.
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申请公布号 |
US2005196451(A1) |
申请公布日期 |
2005.09.08 |
申请号 |
US20040932043 |
申请日期 |
2004.09.02 |
申请人 |
BODENTEICH ANGELIKA;PIRICH EBERHARD;BOCKMANN JOSEF;FRANTSITS WERNER |
发明人 |
BODENTEICH ANGELIKA;PIRICH EBERHARD;BOCKMANN JOSEF;FRANTSITS WERNER |
分类号 |
A61K9/20;A61K9/28;A61K31/4453;C22C26/00;(IPC1-7):A61K31/445;A61K9/14 |
主分类号 |
A61K9/20 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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