发明名称 |
Dimeric small molecule potentiators of apoptosis |
摘要 |
Caspase activity and apoptosis are promoted using active, dimeric Smac peptide mimetics of the general formula M1-M2, wherein moieties M1 and M2 are monomeric Smac mimetics and L is a covalent linker. Target cancerous or inflammatory cells are contacted with an effective amount of an active, dimeric Smac mimetic, and a resultant increase in apoptosis of the target cells is detected. The contacting step may be effected by administering to a pharmaceutical composition comprising a therapeutically effective amount of the dimeric mimetic, wherein the individual may be subject to concurrent or antecedent radiation or chemotherapy for treatment of a neoproliferative pathology.
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申请公布号 |
US2005197403(A1) |
申请公布日期 |
2005.09.08 |
申请号 |
US20050070733 |
申请日期 |
2005.03.01 |
申请人 |
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM |
发明人 |
HARRAN PATRICK G.;WANG XIAODONG;DE BRABANDER JEF K.;LI LIN;THOMAS RANNY M.;SUZUKI HIDETAKA |
分类号 |
A61K31/165;(IPC1-7):A61K31/165 |
主分类号 |
A61K31/165 |
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