发明名称 |
Cyclic GMP-binding, cyclic GMP-specific phosphodiesterase materials and methods |
摘要 |
The present invention provides novel purified and isolated nucleotide sequences encoding the cGMP-binding. cGMP-specific phosphodiesterase designated cGB-PDE. Also provided by the invention are methods and materials for the recombinant production of cGB-PDE polypeptide products and methods for identifying compounds which modulate the enzymatic activity of cGB-PDE polypeptides.
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申请公布号 |
US2005196833(A1) |
申请公布日期 |
2005.09.08 |
申请号 |
US20030353575 |
申请日期 |
2003.01.28 |
申请人 |
ICOS CORPORATION AND UNIVERSITY OF WASHINGTON |
发明人 |
BEAVO JOSEPH A.;CORBIN JACKIE D.;FERGUSON KENNETH M.;FRANCIS SHARRON H.;KADLECEK ANN;MCALLISTER-LUCAS LINDA M.;LOUGHNEY KATE;SONNENBURG WILLIAM K.;THOMAS MELISSA K. |
分类号 |
C12N15/02;C07H21/04;C07K16/40;C12N1/21;C12N5/10;C12N5/12;C12N9/16;C12N15/09;C12N15/55;C12P21/08;C12Q1/02;C12Q1/44;C12Q1/68;C12R1/645;(IPC1-7):C12N9/16;A61K31/519 |
主分类号 |
C12N15/02 |
代理机构 |
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地址 |
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