| 摘要 |
<p>The present invention relates to a mammal with inducible ductal carcinoma in situ (DCIS), the mammal containing (a) an oncogene which can be activated by lactotropic hormones and (b) a mutated tumor suppressor gene resulting in a tumor suppressor protein showing a partial or complete loss of activity. The invention also relates to a method of producing such a mammal and its use for studying (a) a DCIS or the progression thereof towards invasive ductal carcinoma of the breast and/or (b) the oncogenic potential of mutations of tumor suppressor genes, preferably p53, as well as for developing diagnostic and therapeutic means for the above purpose.</p> |
