发明名称 |
Ultrasonic imaging system utilizing a long-persistence contrast agent |
摘要 |
A microbubble preparation formed of a plurality of microbubbles comprising a first gas and second gas surrounded by a membrane such as a surfactant, wherein the first gas and the second gas are present in a molar ration of from about 1:100 to abut 1000:1, and wherein the first gas has a vapor pressure of at least about (760-X) mm Hg at 37° C., where x is the vapor pressure of the second gas at 37° C., and wherein the vapor pressure of each of the first and second gases is greater than about 75 mm Hg at 37° C.; also disclosed are methods for preparing microbubble compositions, including compositions that rapidly shrink from a first average diameter to a second average diameter less than about 75% of the first average diameter and are stabilized at the second average diameter; methods and kits for preparing microbubbles; and methods for using such microbubbles as contrast agents.
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申请公布号 |
US6939531(B2) |
申请公布日期 |
2005.09.06 |
申请号 |
US20030644634 |
申请日期 |
2003.08.19 |
申请人 |
IMCOR PHARMACEUTICAL COMPANY |
发明人 |
SCHUTT ERNEST G.;ANDERSON CHARLES DAVID;EVITTS DAVID P. |
分类号 |
A61K49/00;A61B8/00;A61K49/22;B01J13/02;F21V8/00;(IPC1-7):A61B8/00;A61K9/14 |
主分类号 |
A61K49/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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