发明名称 |
Method for preparing dexchlor tannate |
摘要 |
The invention pertains to a method for preparing dexchlorpheniramine ("dexchlor") tannate by reacting dexchlorpheniramine free base at a temperature of about 75 to about 150° C. with tannic acid neat or as an aqueous slurry containing up to about 20 wt. % water. The dexchlorpheniramine free base may be obtained by reacting a commercially available dexchlorpheniramine salt such as dexchlorpheniramine maleate with a base such as aqueous sodium hydroxide. The resultant dexchlor tannate has extended release properties and is useful in pharmaceutical compositions as an antihistamine for human beings.
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申请公布号 |
US6939856(B2) |
申请公布日期 |
2005.09.06 |
申请号 |
US20030641533 |
申请日期 |
2003.08.14 |
申请人 |
JAME FINE CHEMICALS, INC. |
发明人 |
REDKAR SHAM N.;ACHARI RAJA G.;MELLOZZI ANGELO R.;CHOPDEKAR VILAS M. |
分类号 |
A61K31/4402;C07D213/38;(IPC1-7):A61K31/702;A61K31/70;C07H13/02;C07C69/88 |
主分类号 |
A61K31/4402 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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